Dani Ceballos, Gareth Bale, Marcelo, Ferland Mendy and Dani Carvajal remain on the treatment table for Los Blancos, while Marco Asensio, Isco and Mariano Diaz have been late withdrawals from the squad.
Head coach Carlo Ancelotti will make changes from the side that took to the field for the shock Champions League loss to Sheriff Tiraspol, with Lucas Vazquez pushing to feature at right-back, which could see Nacho move to the opposite side.
Eden Hazard found it difficult to make his mark against Sheriff and is unlikely to start, while Asensio is seemingly viewed as more of a midfielder by his manager this term, and the Spaniard will not be available here due to a muscular issue.
Rodrygo came off the bench during Tuesday's Champions League defeat, and the Brazilian could now earn a start as part of a front three.
Real Madrid possible starting lineup: Courtois; Vazquez, Militao, Alaba, Nacho; Valverde, Casemiro, Kroos; Vinicius, Benzema, Rodrygo