The 23-year-old, used for an hour in the win over Leganes last time out, starts a European match for just the fourth time this season.
The visitors have a number of injury problems to contend with, meanwhile, finding themselves without Arturo Vidal, Arjen Robben, Jerome Boateng, Kingsley Coman, Manuel Neuer and now Javi Martinez for his huge fixture.
Robert Lewandowski leads the Bayern line as expected, aiming to build on a record that has seen him score 39 times in all competitions this season, while James Rodriguez starts against his parent club.
Bayern show four changes from last week's first leg, which finished 2-1 to back-to-back champions Madrid.
Real Madrid: Navas; Vazquez, Ramos, Varane, Marcelo; Modric, Kovacic, Kroos; Asensio, Benzema, Ronaldo
Subs: Casilla, Nacho, Bale, Casemiro, Theo Hernandez, Mayoral, Ceballos
Bayern Munich: Ulreich; Kimmich, Hummels, Sule, Alaba; Thiago; Muller, Tolisso, James, Ribery; Lewandowski
Subs: Starke, Wagner, Martinez, Rafinha, Mai, Rudy, Dorsch
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