The two sides will meet again in the Bernabeu on Tuesday night - a ground where Madrid have won their last seven Champions League matches in succession.
They also have a positive record against clubs from Germany on their home turf, having lost twice against Bayern Munich from 23 meetings in total.
In contrast to Madrid's good record, Dortmund have only been able to emerge victorious from one of their eight trips to Spain.
They are likely to be without midfielder Jakub Blaszczykowski, who is struggling with a muscular complaint.
R Madrid: WWWLW
B Dortmund: DWWWL
Possible starting lineups:
R Madrid: Casillas; Ramos, Varane, Pepe, Essien; Di Maria, Modric, Alonso, Ozil; Ronaldo, Benzema
B Dortmund Weidenfeller; Piszczek, Hummels, Subotic, Schmelzer; Kehl, Gundogan, Leitner, Reus, Gotze; Lewandowski
Sports Mole says: 3-1