Both Madrid and Roma have collected nine points from their four Group G matches this term, and a win for either would see them advance to the knockout round of the competition with a match to spare.
Here, Sports Mole takes a look at how Madrid could line up in Italy on Tuesday night.
Madrid boss Santiago Solari might be keen to ring the changes following the disappointing defeat at Eibar, but the capital giants do not have that many first-team options.
Indeed, Nacho and Casemiro remain on the sidelines, while Alvaro Odriozola was forced off against Eibar and is expected to be unavailable.
Dani Carvajal replaced Odriozola on Saturday and should be ready to return to the XI, though, as part of Madrid's first-choice defensive unit.
Dani Ceballos was particularly disappointing against Eibar, and his midfield spot could be taken by Isco, with Lucas Vazquez also potentially coming into the XI at the expense of the out-of-form Marco Asensio.