Los Blancos have lost four of their last five matches in all competitions, and there will be intense pressure on the European champions to return to winning ways ahead of this weekend's El Clasico at Camp Nou.
The capital giants have the small matter of a trip to Barcelona in La Liga this weekend, but simply must return to winning ways in this match in order to avoid what would be a full-blown crisis. Indeed, it is already their worst run of results for almost 10 years.
Here, Sports Mole takes a look at how Madrid could line up at the Bernabeu.
Out: Dani Carvajal (calf)
Karim Benzema and Gareth Bale both came off the bench in Saturday's 2-1 defeat to Levante, and the pair, who have been carrying knocks, should return to the starting XI for this match due to its importance.
Mariano Diaz and Lucas Vazquez would be the likeliest to drop out, although Marco Asensio struggled to impress against Levante, while Isco looked far from match fit following appendix surgery, and both are under threat.
Neither Toni Kroos nor Nacho were involved against Levante, but the former should return to the middle of midfield, while the latter is expected to replace Alvaro Odriozola at right-back with Dani Carvajal still on the sidelines with a calf complaint.
There have been calls for Keylor Navas to replace Thibaut Courtois between the sticks, but the Belgium international should keep his spot in the XI despite struggling to impress since being promoted to the club's number one.