QPR are currently at the foot of the Premier League table with just four points from 11 matches, while the Saints are just a point and a place above them.
"My future does not depend on this match at all," said Hughes on Friday. "Of course, the club wants to move forward and the focus is rightly on the results.
"This is a key Premier League game and one we can win. It's for others to call it a must-win game.
"It's up to us to turn this around. We know that and that's exactly what we're trying to do, as staff and players."
Hughes was appointed the QPR manager in January 2012.