QPR are currently bottom of the Premier League form table, having picked up just one point from their last six games.
Hughes saw his side lose 1-0 to Newcastle in his first game in charge, but a win over MK Dons in an FA Cup replay gave Rangers their first win in 11 games, and Hughes is eyeing Saturday's relegation clash as a perfect chance to get more points on the board.
"We are all mindful of the significance of the game," said the 48-year-old manager.
"It is not only this one but maybe the next six, seven or eight games, to be perfectly honest. They are key to how our season will progress.
"If we can get a positive result at the weekend then that will sustain us for the games we have ahead."
Hughes will have captain Joey Barton available for the first time after the midfielder completed his suspension.