Both teams are currently in the relegation zone, although a win for either side could see them climb out of the bottom three.
Hughes, who took charge for the first time for Sunday's 1-0 defeat at Newcastle United, will be without captain Joey Barton, who is still serving a suspension.
Barton's absence aside, the Welshman has no new injury problems.
Shaun Maloney could make a return to the Latics side following a calf injury, while there are no other concerns for manager Roberto Martinez.
QPR: Kenny; Hill, Gabbidon, Ferdinand, Young; Derry, Buzsaky, Wright-Phillips, Mackie; Bothroyd, Helguson
Wigan: Al Habsi; Alcaraz, Caldwell, Stam, Figueroa; McCarthy, Crusat, Moses, Gomez; Sammon, Rodallega
Sports Mole says: 2-0