Joao Felix should be in contention for this encounter, but the reigning champions are still without Nuno Mendes as the teenager attempts to recover from a thigh injury, while Nelson Semedo's spot at right-back is safe after Joao Cancelo's positive coronavirus test.
Mendes's injury means that Borussia Dortmund's Raphael Guerreiro is set for another run-out on the left flank, despite his unfortunate own goal in his side's defeat to Germany on matchday two.
Ruben Dias also turned the ball into his own net on the day but is set to keep his place alongside a 38-year-old Pepe, while Rui Patricio will hope to quickly banish the memories of the weekend's 4-2 loss.
Santos has affirmed that alterations could be made, and one man who could benefit from some rotation is Renato Sanches, who has appeared twice in a row off the bench and could challenge William Carvalho for a place in the middle.
Cristiano Ronaldo has failed to score against France in six previous attempts, but the five-time Ballon d'Or winner would set a new record of 20 goals at the World Cup and Euros combined with a strike here - surpassing Miroslav Klose's 19.
Portugal possible starting lineup: Patricio; Semedo, Dias, Pepe, Guerreiro; Pereira, Sanches, Fernandes; B.Silva, Ronaldo, Jota