Pacos de Ferreira vs. Belenenses (Friday, 3.00pm)
Meanwhile, the last time that the visitors claimed all three points at the Estadio de Mata Real was back in March 2008.
We say: Pacos de Ferreira 1-1 Belenenses
Pacos de Ferreria beat Belenenses 2-0 in January, however since then, the form for both sides has flipped, which could mean that Friday's contest is a much closer affair.
A high-scoring game is not expected at the Estadio da Mata Real and with little to separate the two teams, a draw could be on the cards.
Guimaraes vs. Moreirense (Friday, 5.00pm)
The hosts have lost eight of their last 10 league matches, while the visitors have won just one of their last seven games in the top-flight.
We say: Vitoria de Guimaraes 1-1 Moreirense
Both Vitoria de Guimaraes and Moreirense have struggled for points in recent weeks, but a win on Friday could help turn their fortunes around heading down the home straight.
The last three meetings between the two teams have ended as score draws and with little to separate them, another score draw could be on the cards at the Estadio D. Afonso Henriques.
Tondela vs. Benfica (Friday, 7.00pm)
The hosts head into this game having won eight of their 10 top-flight matches on home soil this season, while the Eagles have taken an impressive 24 points from the last 27 available.
We say: Tondela 1-3 Benfica
Benfica have won all five of their previous meetings away at Tondela in the top-flight by an aggregate score of 15-2. The Eagles will be strong favourites for Friday's clash, and we expect them to claim all three points once again at the Estadio Joao Cardoso.
Porto vs. Famalicao (Friday, 9.15pm)
The hosts have not lost any of their last 23 league matches, while the visitors are unbeaten in their previous three away games, scoring eight goals in the process.
We say: Porto 1-0 Famalicao
Famalicao have the quality in their ranks to compete with Porto on Friday, and they could make it a difficult evening for the hosts. However, we expect Conceicao's men to come out on top and secure a narrow victory at the Estadio do Dragao.