Loan star Hobbs has been recalled by parent club Hull City and therefore is not available to take his usual place in the centre of Forest's defence.
Lansbury is serving a ban, so Radoslaw Majewski is recalled to fill the void left by the reported Fulham target in midfield, while Simon Cox continues in attack having watched from the bench during Halford's run as a makeshift forward.
Preston are also missing a leading figure through suspension, with experienced striker Kevin Davies forced to sit out of the match at the City Ground after being sent off against Coventry City last weekend.
Forest: Darlow; Jara, Halford, Collins, Lichaj; Vaughan, Mackie, Majewski, Reid, Paterson; Cox
Subs: De Vries, Harding, Lascelles, Moussi, Abdoun, Henderson, Derbyshire
Preston: Rudd; Wiseman, Clarke, Wright, Buchanan; Welsh, Brownhill, Kilkenny, Humphrey; Gallagher, Garner
Subs: Stuckmann, King, Laird, Hume, Beavon, Holmes, Keane