The Bluebirds are bottom of the table and could be relegated back to the Championship if they fail to win and other results go against them this weekend.
While Cardiff, who are two points from safety with a trip to Stamford Bridge to come, are staring at the trapdoor, Alan Pardew could also be on borrowed time at St James' Park following a run of six consecutive top-flight defeats - Newcastle's worst league run in 27 years.
The latest of these came courtesy of a 3-0 loss at Arsenal on Monday, during which fan protests against the Magpies' lack of progress under the 52-year-old's management were clearly evident.
A victory this weekend in their last home game of the season may calm the Toon Army's concerns and would also condemn Cardiff to the drop, if either Norwich City or Sunderland are winners.
Mark Hudson and Craig Noone are also out for the Welsh outfit, whose manager Ole Gunnar Solskjaer may recall Wilfried Zaha in place of Don Cowie to give them a greater attacking threat from the flanks.
Newcastle's own unpredictable winger, Hatem Ben Arfa, appears to be on his way out of the club after being omitted from the squad that travelled to Arsenal, amid reports of a bust-up with Pardew.
With the Frenchman firmly out of favour and Newcastle's attacking options further limited by injuries to Papiss Cisse and Luuk de Jong, Pardew could name the same side that were brushed aside in London.
Newcastle have failed to score in five of their previous six games, and have only found the net once in the 11 matches that top goalscorer, Queens Park Rangers loanee Loic Remy, has missed this season.
Possible starting lineups
Newcastle: Krul; Debuchy, Williamson, Coloccini, Dummett; Tiote, Anita, Gosling; Sissoko, Gouffran, Remy
Cardiff: Marshall; Theophile-Catherine, Caulker, Turner, Fabio; Zaha, Medel, Whittingham, Mutch; Daehli; Campbell
Sports Mole says: 1-1