Bruce has hinted that Dubravka and Saint-Maximin are the most likely of the quartet to retain their places, but much will depend on training on Friday.
Despite scoring in six successive games, Willock may be replaced by Sean Longstaff ahead of returning to parent club Arsenal in the summer.
If Dubravka does not pass a fitness test, Mark Gillespie should be provided with his first-ever start in the Premier League.
Top goalscorer Callum Wilson has already been ruled out of the last game, but Bruce will not mind his key man enjoying a longer rest ahead of the next campaign.
Fabian Schar is available again after suspension, while Bruce will give consideration to handing at least one prospect some minutes in the second half.
Newcastle United possible starting XI: Gillespie; Schar, Clark, Dummett; Murphy, Longstaff, Shelvey, Almiron, Ritchie; Gayle, Carroll
Watch the Sports Mole Football Shorts prediction for this game below: