Championship strugglers Wednesday were held to a goalless draw by their League One opponents when they previously met at Hillsborough on January 5.
Wednesday boss Dave Jones could rest a number of key figures as he looks to get the club away from the relegation zone in the league.
MK Dons: WLLWDD
Sheff Weds: WWDLDW
MK Dons: Martin; Chicksen, Kay, Williams, Lewington (c); Potter, Harley; Powell, Lowe, Bowditch; McLeod
Sheff Weds: Bywater; Buxton, Taylor, Mattock, Llera; Antonio, McCabe, Lee, Helan; Maguire, Sidibe
Sports Mole says: 1-2