The home side's form has not been overly positive of late, but they have been boosted by the recent arrival of striker Nathan Tyson, who may be handed his first start for the club on Friday night.
The last time these two sides met in this competition back in 1986, Millwall advanced through thanks to a 1-0 victory after the first tie had ended in a 1-1 draw at Villa Park.
Aston Villa: LLLDLD
Possible starting lineups:
Millwall: Forde; A.Smith, J.Smith, Abdou, Shittu; Beevers, Woolford, Trotter, Henry; Keogh, Tyson
Aston Villa: Given; Vlaar, Clark, Bennett, Lowton; Ireland, N'Zogbia, Delph, Weimann; Agbonlahor, Bent
Sports Mole says: 1-1