The Red Devils are unbeaten in nine top-flight matches, winning the last two of those, while Brighton have also won back-to-back games to ease their relegation concerns.
Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Bailly, Maguire, Shaw; Pogba, Fred; James, Fernandes, Rashford; Cavani
BRIGHTON & HOVE ALBION
Sports Mole's predicted XI: Sanchez; White, Dunk, Burn; Gross, Bissouma, Lallana, Moder; Trossard; Maupay, Welbeck
Watch the Sports Mole Football Shorts prediction for this game below: