The forward was left on the bench as an unused substitute during Thursday's 2-0 win over Granada in the second leg of their Europa League quarter-final on Thursday night due to a slight fitness concern.
However, Ole Gunnar Solskjaer is hopeful of having him back available, which could spell bad news for Mason Greenwood, who appears to be first in line to drop out despite scoring in his last two Premier League games.
Greenwood's latest strike means that only Wayne Rooney has scored more top-flight goals for Man United as a teenager, but his position is the most vulnerable with Edinson Cavani set to lead the line once again, Bruno Fernandes playing behind the striker and Paul Pogba on the left.
Anthony Martial is the highest profile absentee for the hosts, who are expected to be without the Frenchman for the remainder of the season due to a knee injury.
Manchester United possible starting lineup:
Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, Pogba; Cavani
Watch the Sports Mole Football Shorts prediction for this game below: