The Colombian striker joined the Red Devils on a season-long loan deal from Monaco on transfer deadline day, and some reports had suggested that he would be included in the starting lineup at Old Trafford.
Elsewhere, Daley Blind will make his first appearance for United as a wing-back, while Rafael da Silva has replaced Antonio Valencia on the right flank. Darren Fletcher has also dropped out of the team, with the fit again Ander Herrera replacing the Scot.
Man United: De Gea; Evans, Rojo, Blackett; Rafael, Blind; Herrera, Mata, Di Maria; Rooney, Van Persie
QPR: Green; Hill, Ferdinand, Caulker, Isla; Sandro, Kranjcar, Fer; Phillips, Hoilett, Austin
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