The France international was doubtful for the match due to his late return to training following his exploits with France at the World Cup.
Pogba is thrown straight into the starting lineup, however, and is named captain by boss Jose Mourinho for the clash at Old Trafford.
In terms of the visitors, the big news is that manager Claude Puel has handed a start to Harry Maguire, despite hinting earlier this week that the Man United target would only be fit enough for a place on the bench.
City fans get a chance to see Ricardo Pereira and James Maddison in a competitive match for the first time since their arrivals over the summer, while Jonny Evans and Rachid Ghezzal are both among the subs.
Manchester United: De Gea; Shaw, Lindelof, Bailly, Darmian; Pogba, Pereira, Fred; Sanchez, Rashford, Mata
Subs: Grant, Smalling, Young, Fellaini, McTominay, Martial, Lukaku
Leicester City: Schmeichel; Amartey, Morgan, Maguire, Chilwell; Ndidi, Silva; Ricardo, Maddison, Gray; Iheanacho
Subs: Ward, Evans, Vardy, Albrighton, Iborra, Fuchs, Ghezzal
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