Marouane Fellaini starts on the south coast after coming off the bench to score against Arsenal last time out, while Anthony Martial, Marcus Rashford, Juan Mata, Marcos Rojo and Matteo Darmian are the other new additions.
Meanwhile, hosts Brighton have made two changes for the game, with Glenn Murray starting up front in place of Leonardo Ulloa and Davy Propper coming back from suspension to replace Beram Kayal in midfield.
Steve Sidwell, who is still recovering from an ankle injury, was the Seagulls' only absentee ahead of the match.
Brighton & Hove Albion: Ryan; Bruno, Duffy, Dunk, Bong; Knockaert, Stephens, Propper, Izquierdo; Gross; Murray
Subs: Kayal, Ulloa, Goldson, March, Schelotto, Locadia, Krul
Manchester United: De Gea; Young, Rojo, Smalling, Darmian; Pogba, Herrera, Fellaini; Martial, Rashford, Lingardford, Martial
Subs: Romero, Bailly, Lindelof, Shaw, Herrera, McTominay, Lingard
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