The Frenchman had been ruled as a major doubt for the encounter by Gunners manager Arsene Wenger after he was forced off at half time of the 5-0 victory over Huddersfield Town on Wednesday with a groin complaint but recovers to lead the line tonight.
Wenger is able to name an identical starting XI as he did against the Terriers as he looks to extend a 12-game winning run at home, with Alexis Sanchez overcoming a minor hamstring problem to partner Mesut Ozil as attacking support for Lacazette.
As for United, Jose Mourinho also names an unchanged starting lineup following the 4-2 victory at high-flying Watford in midweek, with Nemanja Matic passed fit to start in midfield despite limping off early against the Hornets.
Zlatan Ibrahimovic is missing entirely for the visitors, having featured four times from the bench since his recovery from a serious knee injury.
Victor Lindelof, Chris Smalling and Marcos Rojo make up an unchanged backline ahead of David de Gea in goal, while options on the bench include Marcus Rashford, Juan Mara, Henrikh Mkhitaryan and Ander Herrera.
Arsenal: Cech; Koscielny, Mustafi, Monreal; Bellerin, Ramsey, Xhaka, Kolasinac; Ozil, Sanchez; Lacazette
Subs: Ospina, Mertesacker, Coquelin, Wilshere, Iwobi, Welbeck, Giroud
Manchester United: De Gea; Lindelof, Smalling, Rojo; Valencia, Matic, Pogba, Young; Lingard, Martial; Lukaku
Subs: Romero, Darmian, Blind, Mkhitaryan, Herrera, Mata, Rashford
Keep up with all of the action from the Emirates this evening with Sports Mole's live text commentary here.