Dimitar Berbatov misses out for Fulham while Wayne Rooney partners Robin van Persie for Manchester United.
Dimitar Berbatov has not been passed fit after his knock against West Ham United, so Fulham manager Martin Jol has named Hugo Rodallega up front with Bryan Ruiz in behind.
United manager Sir Alex Ferguson has named an attacking side that includes Wayne Rooney up front alongside Robin van Persie.
Ferguson has also opted for Nani, Antonio Valencia and Tom Cleverley in the midfield, while Chris Baird starts in the middle for Fulham.
Fulham: Schwarzer; Reither, Senderos, Hangeland, Riise; Karagounis, Baird, Duff, Dejagah, Ruiz; Rodallega
United: De Gea; Rafael, Ferdinand, Evans, Evra; Valenica, Carrick, Cleverley, Nani; Rooney, Van Persie