The Royals come into the match four points off the relegation zone and without a win against United in nine meetings.
Meanwhile, the Red Devils could find their lead cut to nine points when play gets underway if Manchester City defeat Everton in Saturday's early kickoff.
The hosts have Nani missing through injury, but Phil Jones could return to the squad. Nemanja Vidic is expected to return to the starting lineup after the captain missed Sunday's 2-2 draw with Chelsea in the FA Cup quarter-finals.
Man Utd: DWWWLD
Possible starting lineups
Man Utd: De Gea; Rafael, Ferdinand, Vidic, Evra; Carrick, Cleverley, Giggs; Kagawa; Van Persie, Rooney
Reading: Taylor; Pearce, Mariappa, Harte, Kelly; Leigertwood, McAnuff, Akpan, McCleary, Hunt; Le Fondre
Sports Mole says: 2-0