On the other hand, David Moyes's United have picked up four points from their opening two matches of the campaign, hammering Swansea City 4-1 away from home before drawing 0-0 with Chelsea at Old Trafford on Monday.
United will know that winning at Anfield will be a huge boost in their attempt to retain the league title, but will have to do so without the injured trio of Javier Hernandez, Rafael da Silva and Nani.
Manchester United: WD
Possible starting lineups
Liverpool: Mignolet; Johnson, Skrtel, Agger, Enrique; Lucas, Gerrard, Henderson; Aspas, Coutinho; Sturridge
Manchester United: De Gea; Jones, Ferdinand, Vidic, Evra; Carrick, Cleverley; Valencia, Rooney, Welbeck; Van Persie
Sports Mole says: 1-2