The North London side host the Premier League champions for the first time since their humiliating 8-2 defeat at the hands of the Red Devils and will be hoping to avoid a repeat of that crushing scoreline.
The Gunners are unlikely to call upon loan signing Thierry Henry as the striker is dealing with a calf strain. Another blow to Arsene Wenger's side is the loss of Mikel Arteta, who is expected to miss out as he continues to deal with a leg problem.
While Arsenal are still dealing with a number of casualties, Johan Djourou and Ignasi Miquel are likely to start in defence at the Emirates, with Robin van Persie leading the line for the North London side.
Paul Scholes scored at Old Trafford on Saturday but could drop down to the bench alongside Nani, who is likely to make way for Ji-Sung Park. Javier Hernandez is expected to partner Wayne Rooney up front as Danny Welbeck recovers from an injury.
Manchester United: WWWLLW
Arsenal: Szczesny; Djourou, Mertesacker, Koscielny, Miquel; Song, Ramsey, Benayoun; Walcott, Arshavin, Van Persie
Manchester United: De Gea; Rafael, Ferdinand, Evans, Evra; Valencia, Anderson, Carrick, Park; Rooney, Hernandez
Sports Mole says: 1-2