West Ham vs. Man Utd (Sunday, 2.00pm)
The Red Devils suffered a 2-1 loss to Young Boys in their opening group-stage fixture on Tuesday, but West Ham started their Europa League challenge with an impressive 2-0 success away to Dinamo Zagreb.
We say: West Ham United 1-2 Manchester United
This is an incredibly difficult match for Man United, but the absence of Antonio for West Ham is a huge boost for Solskjaer's side. It would not be a surprise to see a home victory or a draw at the London Stadium, but we just have a feeling that the Red Devils will do enough to secure a narrow win in the capital, having had longer to prepare for the contest.
Brighton vs. Leicester (Sunday, 2.00pm)
The Foxes are currently ninth in the table with six points to show from their four matches, while Brighton occupy sixth, having picked up nine points from their first four fixtures of the 2021-22 campaign.
We say: Brighton & Hove Albion 2-2 Leicester City
Leicester are struggling to gain any sort of momentum in the early stages of the season, and they will be taking on a Brighton side full of confidence following a strong start. We are expecting goals at the Amex on Sunday and have had to settle on a draw taking everything into consideration.
Spurs vs. Chelsea (Sunday, 4.30pm)
We say: Tottenham Hotspur 0-1 Chelsea
Spurs' injury problems in attack are mounting, but the potential returns of Sanchez and Romero will at least ease their concerns on the defensive front before Tuchel's rampant forces pay a visit.
It is difficult to envisage Chelsea banking multiple goals in the capital if Santo has his first-choice backline available, but the visitors' own staunch rearguard action should shine through as they scrape a narrow win at the Tottenham Hotspur Stadium.