The Red Devils take on Manchester City on Sunday before games against AC Milan (twice), West Ham United and Leicester City in three different competitions, meaning that the visit to Palace is one of their easiest matches on paper this month.
Solskjaer could therefore use the opportunity to rest players where possible, with the likes of Eric Bailly, Alex Telles, Dean Henderson and Nemanja Matic pushing for inclusion after sitting out at the weekend.
Daniel James and Scott McTominay both overcame slight niggles to start in Sunday's goalless draw with Chelsea, but the latter in particular has picked up a few knocks recently and Solskjaer may give him the night off at Selhurst Park.
Donny van de Beek was also included in the matchday squad at Stamford Bridge despite slight concerns over his fitness, and he will be desperate for more game time against the team he scored against on his Man United debut in September.
The main injury doubt heading into this match is Edinson Cavani, who once again missed out at the weekend due to a muscle problem and will be assessed ahead of kickoff in midweek.
There could be a temptation to rest Bruno Fernandes, who has had a direct hand in 40 goals from his 40 Premier League appearances so far, but has failed to register a goal or an assist in his last three trips to the capital.
United have generally struggled to reach their usual standard when Fernandes is not on the pitch, though, so Solskjaer is likely to keep the Portuguese playmaker in his starting lineup for this one too.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Bailly, Maguire, Telles; Matic, Fred; James, Fernandes, Rashford; Cavani
Watch the Sports Mole Football Shorts prediction for this game below: