Ronaldo has only played 45 minutes of football during pre-season - the first half against Rayo Vallecano last weekend - due to a personal issue, but he is also said to be pushing to leave the club this summer.
The Portuguese had been in line for a spot on the bench this weekend, but Anthony Martial is out of this match with a hamstring problem, meaning that Ten Hag could be forced to start the 37-year-old.
Sancho has not been pictured in training with the Red Devils this week after missing out against Atletico Madrid last weekend through illness, and he is facing a race to prove his fitness.
There is expected to be a debut at the heart of the defence for Lisandro Martinez, while fellow new signing Tyrell Malacia could start at left-back, with Luke Shaw also missing last weekend through illness.
Manchester United possible starting lineup: De Gea; Dalot, Maguire, L Martinez, Malacia; Fred, McTominay; Sancho, Fernandes, Elanga; Rashford