Hughes declared in the build-up to last weekend's clash that United had lost their aura and looked more vulnerable, but now believes that Moyes will be a success once he has imposed a defined style of play.
He told the Daily Mail: "No, come on, what's he had? Nine games?
"David Moyes will be manager for a long time. He'll be given time and has good players who'll win enough games for him this year, even if it's a difficult season. Once he gets his philosophy over, he'll be fine."
Hughes has plenty of experience of pressures Old Trafford built during two separate spells during his playing career, with Welshman passing 450 appearances for United in 1995.