United's away clash against the Saints will be a milestone for the Scotsman, and he is keen on garnering their second successive victory in the Premier League this season.
"I could never imagine how long I would be at the club or that I would be looking forward to my 100th game," Ferguson is quoted as saying in The Daily Mail.
"It may be a special occasion but it's just another game that I want to win."
Ferguson has been at the helm of United since 1986 and said that he is proud to have worked with a whole host of great players over the years.
"There have been so many wonderful players at the club and it has been a pleasure and an honour working with them," said the 70-year-old.
"There's nothing I like better than to pull my car into the training ground of a morning and look forward to another few hours working with them and my staff.
"Any manager would be thankful to remember one great squad; I've had five or six."