It will be the first time that the arch rivals go head to head this season, with Anfield hosting the encounter for a lunchtime kickoff.
United currently sit second in the Premier League table, level on points with leaders Manchester City after seven games, while Liverpool reside seven points adrift.
"It's always a hard test when you are going to Anfield," Coton told Sky Sports News. "You know what those games are like. This will be a test of where Manchester United stand. If they go there and get a victory the momentum is all going forward."
Both league encounters between the two clubs ended in draws last season.