Ole Gunnar Solskjaer's side are currently second in the division, level on points with leaders Liverpool, meaning that a draw at Turf Moor would see them rise to the summit ahead of next weekend's clash between the top two.
The 20-time English champions will enter the league contest off the back of a 1-0 win over Watford in the third round of the FA Cup.
Here, Sports Mole looks at how United could line up against Sean Dyche's side, who have picked up 16 points from their 15 league games this season to occupy 16th position.
Solskjaer revealed after Saturday's clash with Watford that Victor Lindelof, Paul Pogba and Luke Shaw were all injured for the FA Cup fixture rather than rested, but it would not be a surprise to see all three players named in the starting XI at Turf Moor.
Phil Jones and Facundo Pellistri are definitely unavailable, while Marcos Rojo is unlikely to feature; Eric Bailly is also a huge doubt due to the neck injury that the centre-back picked up during a collision with his own goalkeeper Dean Henderson on Saturday night.
Marcus Rashford, Fred, David de Gea and Bruno Fernandes will definitely be back in the side against Burnley, while Nemanja Matic is an option for the middle of the park if Solskjaer decides to rest McTominay, who played the full 90 minutes against Watford.
Watch the Sports Mole Football Shorts prediction for this game below: