Mason Mount could reportedly be on the sidelines for up to one month with a calf strain that he suffered during a training session with Manchester United.
The England international has found it difficult to make his mark for the 20-time English champions since arriving from Chelsea during the summer transfer window.
The attacker has only contributed one assist in 12 appearances for Man United in 2023-24, and he was absent for five matches earlier this term due to a muscular problem.
However, according to the Daily Mail, the playmaker picked up a calf issue during a training session, and he could now be on the sidelines for the next three to four weeks recovering from the problem.
Mount has not started a Premier League match for Man United since the early stages of October, and he now faces a battle to return for their festive period.
If he is absent for a month, the Englishman would miss Premier League matches against Everton, Newcastle United, Chelsea, Bournemouth, Liverpool and West Ham United, ahead of a potential return against Aston Villa on Boxing Day depending on his recovery.
Mount is also set to be ruled out of his side's final two Champions League group-stage fixtures with Galatasaray and Bayern Munich in Istanbul and Manchester respectively.
Rasmus Hojlund is facing a late fitness test on the muscle strain that he suffered during the team's 1-0 win over Luton Town before the international break.
Ten Hag said during his press conference that a decision on the Denmark international's involvement at Goodison Park would be made on Saturday.
However, Ten Hag has firmly denied claims of a rift with Varane, who is widely expected to leave Old Trafford during next summer's transfer window.