Spurs suffered a 1-0 defeat to capital rivals West Ham United in the league last weekend, which has left them in sixth spot in the table entering the next set of fixtures.
However, Nuno Espirito Santo's side will enter this match off the back of a positive result, having recorded a 1-0 victory over Burnley in the last-16 stage of the EFL Cup on Wednesday night.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of the contest with Man United, who lost heavily at home to Liverpool last time out.
Type of injury: Hamstring
Possible return date: Unknown
Ryan Sessegnon was again absent against Burnley on Wednesday night due to a hamstring problem, and it is currently unclear when the former Fulham youngster could be available for selection once again.
Status: Major doubt
Type of injury: Muscle
Possible return date: October 30 (vs. Man United)
Bryan Gil had to be replaced in the 25th minute of the clash with Burnley, having seemingly picked up a muscular problem, and the Spaniard will need to be assessed ahead of this weekend's contest.
TOTTENHAM'S SUSPENSION LIST
Spurs have no players suspended for this match.