Ole Gunnar Solskjaer's side have beaten Arsenal and Chelsea away from home in the last two rounds, and will be favourites to make it a hat-trick of Premier League scalps despite losing their unbeaten domestic record under the Norwegian last weekend.
The FA Cup remains United's best chance of silverware this season despite their unlikely progress in the Champions League, with victory on Saturday taking them into the semi-finals.
Here, Sports Mole looks at how the 12-time winners could line up.
Out: Alexis Sanchez (knee)
Doubtful: Jesse Lingard (hamstring), Mason Greenwood (illness), Antonio Valencia (calf), Matteo Darmian (unspecified), Ander Herrera (hamstring), Juan Mata (hamstring), Phil Jones (illness)
Solskjaer will no doubt use Saturday to shuffle his pack a little, but he will also be wary of doing so too much against as dangerous an opponent as Wolves.
United have played a number of different formations under the Norwegian so far, but the return of Anthony Martial could lead to him switching back to a 4-3-3 this weekend with the in-form Romelu Lukaku leading the line and Marcus Rashford out wide.
Scott McTominay could be handed another opportunity to impress with Nemanja Matic having only recently returned from injury, while Fred may also retain his spot depending on the fitness of Ander Herrera.
Phil Jones is expected to be available again after illness and could start in defence, while Eric Bailly is pushing for his first start since his horror show against Paris Saint-Germain.