It was a night to remember for the Nigerian striker, on loan from Shanghai Shenhua, as he scored his first goal for the club he supported as a boy.
Here, the PA news agency assesses Ighalo's performance.
Taking his chance
Many eyebrows were raised when United announced the signing of Ighalo, whose previous Premier League experience came with Watford. After three substitute appearances, Anthony Martial's injury gave Ighalo the opportunity for a start. And he ticked the box with a goal and a positive display overall.
Leading the line
Ighalo is an out-and-out number nine and he kept Brugge's central defenders busy throughout. His goal was all about reading the game, the striker getting ahead of Clinton Mata and ensuring an easy finish when Juan Mata squared the ball. He certainly offers something different to United's other attackers and showed he can be a good option for Ole Gunnar Solskjaer.
Ighalo was always looking to offer an outlet in the box. He did not have many opportunities but came close to a second shortly after his first with a good turn and smart shot that was pushed away by Simon Mignolet. Was caught offside on a couple of occasions after mistiming his runs and was involved only sporadically during a much less eventful second half.