Man Utd vs. Granada (Thursday, 8.00pm)
Ole Gunnar Solskjaer's side have one foot firmly in the final four after a 2-0 first leg win in Spain, during which Marcus Rashford and Bruno Fernandes struck either side of the half-time whistle.
We say: Manchester United 2-1 Granada
Granada need not take any lessons in putting the ball into the back of the net on unfamiliar territory, and a reshuffled Red Devils rearguard could have Martinez eyeing a spectacular turnaround in the tie. However, an in-form United - albeit one bedevilled by injuries and suspensions - should have too much quality for their inconsistent visitors, so we can only envisage a comfortable second-leg triumph for Solskjaer's men on their way to the semi-finals.
Slavia Prague vs. Arsenal (Thursday, 8.00pm)
The Gunners were minutes away from claiming a 1-0 first-leg win after Nicolas Pepe's late opener, but Tomas Holes scrambled home right at the death to rescue a 1-1 draw and a priceless away goal for Slavia.
We say: Slavia Prague 1-2 Arsenal
The Gunners will hope to take inspiration from their memorable fightback against Benfica as they prepare to step out onto the turf at Slavia's fortress, and defeat here would most likely signal the end of Arsenal's prolonged stint in Europe. Arteta has far more injury concerns to deal with than he would have liked, but a strong showing at Bramall Lane was the perfect tonic for Arsenal before the biggest game of their season so far, and we think they have what it takes to beat Slavia on their own turf and advance to the semi-finals.
Roma vs. Ajax (Thursday, 8.00pm)
Having ended the Dutch giants' 10-game unbeaten home run in the competition, the Giallorossi now seek to capitalise on their advantage from the opening game, with two valuable away goals in hand.
We say: Roma 1-1 Ajax
As the nation's last remaining representatives in Europe this season, Roma can keep the Italian flag flying thanks to their first leg advantage - with experienced campaigners Dzeko, Pedro and Mkhitaryan all poised to play a role in steering their team to a potential semi-final date with Manchester United.
A possible striker shortage for Ajax could keep the scoreline down in what is likely to be an open affair, so they may be left ruing the oversight that sees Sebastian Haller watching on from the sidelines rather than offering a focal point in attack.
Villarreal vs. Dinamo Zagreb (Thursday, 8.00pm)
Gerard Moreno's penalty just before half time proved the difference in last week's reverse fixture, but Dinamo have 90 minutes to respond at Estadio de la Ceramica.
We say: Villarreal 1-0 Dinamo Zagreb (2-0 on aggregate)
Dinamo Zagreb know how to pull off a shock result in Europe, as Tottenham know only too well.
However, the visitors have lost each of their last six games against Spanish opposition, while Villarreal have an incredible record in Europe this term, so we are backing Emery's men to get the job done.