The Red Devils remain top of Group H, level on points with second-placed RB Leipzig, despite suffering a 2-1 defeat away to Basaksehir in the reverse match earlier this month.
United placed themselves in an excellent position to qualify for the last-16 stage of the Champions League when they recorded back-to-back wins over Paris Saint-Germain and Leipzig towards the end of October.
Ole Gunnar Solskjaer's side were brought crashing back down to earth in Turkey on November 4, though, as they suffered a 2-1 loss to Basaksehir to keep the group wide open ahead of the next two fixtures.
A win for United on Tuesday would leave them in a strong spot as one or both of second-placed Leipzig and third-placed PSG will drop points when they lock horns on the same night in Paris.
The Red Devils will enter this game off the back of a 1-0 win over West Bromwich Albion in the Premier League on Saturday night, with Bruno Fernandes scoring the only goal of the contest from the penalty spot.
The 20-time English champions reached the quarter-finals of the 2018-19 Champions League before losing to Barcelona, while they were present in last season's Europa League semi-finals and will be aiming to advance deep into the European Cup this term, despite not being considered as one of the favourites.
There is no question that Basaksehir benefited from some terrible defending from United earlier this month, but it was still an impressive performance from the Turkish side, who are bottom of Group H but level on points with third-placed PSG as they eye another huge result against Solskjaer's side.
The Istanbul giants won their first ever Super Lig title last season and are competing in the group stages of the Champions League for the first time in their history.
Basaksehir have never faced United on English soil, but they did travel to Premier League outfit Burnley in the qualifying rounds of the 2018-19 Europa League, suffering a 1-0 defeat to the Clarets.
Okan Buruk's side will enter this match off the back of a 3-2 defeat to Besiktas in the league on Saturday, which has left them down in sixth position in their domestic table, having collected 13 points from nine matches.
The odds are heavily stacked against the Turkish side heading into Tuesday's clash in Manchester, but they gave a good account of themselves away to Bundesliga side Leipzig earlier this season and have already shown their credentials against Solskjaer's side.
Manchester United Champions League form: WLLWWL
Manchester United form (all competitions): DWLLWW
Istanbul Basaksehir Champions League form: DLLLLW
Istanbul Basaksehir form (all competitions): LWWWLL
Edinson Cavani could again find himself on the bench with Anthony Martial likely to feature through the middle, while David de Gea should keep out Dean Henderson in goal, despite the fact that the England international was given the nod in the reverse game in Turkey.
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Maguire, Tuanzebe, Telles; Fred, McTominay; Rashford, Fernandes, Greenwood; Martial
Istanbul Basaksehir possible starting lineup:
Gunok; Rafael, Skrtel, Epureanu, Bolingoli-Mbombo; Visca, Aleksic, Ozcan, Kahveci, Turuc; Ba
We say: Manchester United 2-0 Istanbul Basaksehir
United will be determined to gain revenge on Basaksehir and secure back-to-back wins at Old Trafford in all competitions. The visitors are certainly capable of making it a difficult game for the Red Devils, but we expect Solskjaer's side to put a third Champions League win of the season on the board.