A famous victory away to Juventus on matchday four means that United now sit second in Group H, just two points behind the Serie A outfit heading into their penultimate match of the group stages.
Another win over Young Boys, coupled with anything other than a Valencia triumph over Juventus, would send Jose Mourinho's side through and take the pressure off their final match against the Spanish outfit.
Here, Sports Mole looks at how the Red Devils could line up for the contest.
Victor Lindelof is expected to miss Tuesday's match after picking up a groin injury during Saturday's goalless draw at home to Crystal Palace.
Eric Bailly was absent from that squad entirely but is likely to come back into the side for his first appearance since October 6 and partner Chris Smalling.
Paul Pogba, Anthony Martial and Romelu Lukaku were among the players to recover from injuries and feature against Palace, but the latter faces a battle to keep hold of his role up front having drawn another blank.