The striker has been an unused substitute for City's last two games after he suffered a broken rib in the international break but is back up front this afternoon as he looks to equalise - and even better - the club's goalscoring record.
Bernardo Silva also works his way into the starting XI, having come off the bench to add gloss in the 7-2 demolition of Stoke City last time out.
After tinkering with his frontline, Pep Guardiola names an otherwise-unchanged lineup from that win over the Potters, with playmaker Kevin De Bruyne leading the midfield alongside David Silva and Fernandinho.
As for Burnley, Sean Dyche keeps faith with the XI that claimed a late draw at West Ham United last Saturday as he looks to extend the side's impressive unbeaten away record this season.
Manchester City: Ederson; Walker, Stones, Otamendi, Delph; Fernandinho, D Silva, De Bruyne; B Silva, Sane, Aguero
Subs: Bravo, Danilo, Mangala, Sterling, Gundogan, Jesus, Toure
Burnley: Pope; Lowton, Tarkowski, Mee, Ward; Arfield, Cork, Hendrick, Defour, Brady; Wood
Subs: Gudmundsson, Bardsley, Westwood, Long, Taylor, Barnes, Lindegaard
Keep up with all of the action from the Etihad this afternoon with Sports Mole's live text commentary here.