Tomorrow, they will take on a Manchester City side at the Etihad Stadium that were beaten 1-0 by 2012 winners Bayern Munich. With the Germans likely to win the group, Roma and City are expected to battle it out for the second qualification spot, meaning that a defeat will put six points between the English champions and their visitors.
City manager Manuel Pellegrini dropped goalkeeper Joe Hart at the weekend, but reports have claimed that the England number one will return to the starting lineup at the expense of Willy Caballero for the visit of the Giallorossi.
Veteran midfielder Frank Lampard has been in positive goalscoring form of late, but he is likely to start among the substitutes again, while Edin Dzeko and Sergio Aguero will continue their partnership up front. Full-back Pablo Zabaleta is also available for selection after his one-match suspension, but Samir Nasri is sidelined with a groin problem.
Roma also have injury concerns of their own, most notably over midfielder Daniele De Rossi, who is a doubt with a calf knock. Defender Davide Astori has also been ruled out with a knee ligament problem.
The Italians have made 14 previous visits to England, but they have won on just one occasion. They were once famously thrashed 7-1 at Old Trafford by City's rivals Manchester United in 2007.
Man City: LDLDWW
Possible starting lineups
Man City: Hart; Zabaleta, Kompany, Demichelis, Kolarov; Milner, Fernandinho, Toure, Silva; Aguero, Dzeko
Roma: De Sanctis; Cole, Manolas, Yanga-Mbiwa, Maicon; Keita, Nainggolan; Pjanic, Totti, Gervinho; Destro
Sports Mole says: 1-0