The Reds trail Manchester City - not in action until Monday evening - by one point at the summit with two games to go.
Liverpool therefore require a helping hand from others, but all Jurgen Klopp's side can do is maintain the pressure on the reigning champions.
However, the Merseyside outfit head into the match on the back of a 3-0 loss to Barcelona in the first leg of their Champions League semi-final tie, and they have won only one of their last seven away league meetings with the Magpies.
Ahead of their visit to the North East on Saturday, Sports Mole looks at how Klopp could set out his side.
Liverpool's injury list had cleared up following the long-awaited returns of Joe Gomez and Alex Oxlade-Chamberlain, who have both been used over the last week, but Keita is now on the sidelines with a groin problem.
The midfielder sustained the damage in the first half of the match at Camp Nou and is unlikely to play any further part this season unless the Reds make it to the Champions League final.
Jordan Henderson replaced Keita against Barca and is almost certain to return to the starting lineup on Saturday, with Klopp expected to name his strongest possible XI.