Nigel Adkins's side go into the match in atrocious form having lost their last six games, a run that has left them eight points clear of safety.
Seventh-placed Liverpool, who are in good form with four wins in their last six, could move within a point of city rivals Everton if they see off Reading.
Possible starting lineups
Reading: Federici; Gunter, Mariappa, Morrison, Kelly; Karacan, Leigertwood, Guthrie, McAnuff, Robson-Kanu; Le Fondre
Liverpool: Reina; Johnson, Carragher, Agger, Enrique; Lucas, Gerrard, Henderson; Downing, Coutinho; Suarez
Sports Mole says: 0-2