The Reds have only dropped two Premier League points this season, winning 25 of their 26 matches during what has been an incredible campaign in England's top flight.
The Merseyside giants will enter this match off the back of a defeat, though, having lost 1-0 to Atletico Madrid in the first leg of their last-16 Champions League tie last week.
Here, Sports Mole looks at how Jurgen Klopp's side could line up at Anfield.
Xherdan Shaqiri and Nathaniel Clyne remain on the sidelines for Liverpool through calf and knee injuries respectively, while Jordan Henderson will miss out with a hamstring problem.
The club captain picked up the issue against Atletico in the Champions League on February 18 and could now be unavailable for selection until the middle of March.
There is unlikely to be any rotation as Liverpool's next game after this one is not until next Saturday against Watford, meaning that 10 of the 11 that started against Atletico are expected to keep their spots.
Keita is being tipped to earn the role alongside Fabinho and Georginio Wijnaldum, but there are unlikely to be any alterations further forward with Mohamed Salah and Sadio Mane again featuring alongside Roberto Firmino.