The champions have picked up just one point and shipped nine goals in their last two top-flight outings, including a highly controversial 2-2 Merseyside derby draw with Everton last time out.
However, they are unbeaten in their last 61 Premier League outings at Anfield, taking 82 points from the last 84 on offer there, and host a Sheffield United side with only one point and two goals to their name this term.
Here, Sports Mole looks at how Jurgen Klopp could line his side up for the contest.
Out: Virgil van Dijk (knee), Alex Oxlade-Chamberlain (knee), Kostas Tsimikas (thigh)
Doubtful: Sadio Mane (leg), Thiago Alcantara (knee), Naby Keita (coronavirus), Joel Matip (muscle), Alisson Becker (shoulder)
Saturday's match will bring an end to Virgil van Dijk's run of starting the last 94 Premier League games for Liverpool, but Wednesday's win at Ajax will have eased concerns over how they will fare without the Dutchman.
Matip could yet be available, but Klopp will not take any risks over his slight muscle injury given how light he is for centre-back options already.
Thiago Alcantara will also undergo a late fitness test ahead of this match, having missed the trip to Amsterdam with the knee injury he sustained in Richarlison's red-card challenge during last weekend's derby.
Like Matip, Klopp is unlikely to take any risks with his fitness, but his injury is not thought to be serious and so he could return to the fold for what would be his first Liverpool game at Anfield.
Jordan Henderson should also return to the starting lineup, despite only being deemed fit enough for 45 minutes during the week, while Naby Keita is expected to be available again and could go straight back into the XI after Georginio Wijnaldum played the full 90 minutes on an energy-sapping surface on Wednesday.
Mane did need ice on his leg following his withdrawal, but Klopp was quick to play down concerns over his fitness, insisting that the winger had a dead leg which was not causing him serious problems.
Adrian is once again expected to start in goal, although Klopp's refusal to completely rule Alisson Becker out of this game has raised hope that the Brazilian will return well ahead of schedule.
Watch the Sports Mole Football Shorts prediction for this game below: