The Merseyside outfit will play Queens Park Rangers at Loftus Road on Sunday before welcoming the European champions to Anfield on Wednesday and then facing Hull City on home turf the following Saturday.
"The best players cannot play every single game at the very top," Rodgers told reporters. "You can break young players and at the age of 26, 27 their careers will be over. Every individual player is different but the number of injuries don't surprise me.
"Our most important game is the next game, and that's QPR. I'll have to look at it but if I want to go with the same team against Real Madrid, I think I can. We won't think about Real until after Sunday's match."
Liverpool have acquired 10 points from a possible 21 in the Premier League so far this season.