Celtic, on the other hand, will be determined to bounce back from their 3-1 loss against AC Milan, with the Scottish team enduring a tough defeat in their first game of the campaign.
Lille's convincing win at the Generali Arena means they currently sit at the top of Group H, with the French team able to take advantage of an early sending-off for Sparta's key defender Ladislav Krejci.
In Ligue 1, Los Dogues have been in fantastic form - currently sitting in second place, with only goal difference separating them and current leaders Paris Saint-Germain.
In fact, they are the only team to remain unbeaten in the French division this campaign, claiming five wins and three draws so far.
Their previous league match resulted in a 1-1 draw away at Nice, with the visitors able to claim a point after going 1-0 down in the early stages of the second half.
Lille have been solid in both attack and defence this season - scoring 17 goals in all competitions, while registering five clean sheets.
Meanwhile, Celtic have got their Europa League campaign off to a poor start, and will be disappointed to have registered a loss against AC Milan.
After going 2-0 down before half time, a strong header by Mohamed Elyounoussi in the 76th minute gave the hosts hope to find the equaliser.
Despite also claiming second place in their domestic league table, Celtic have been underwhelming against fierce rivals Rangers this season.
Although the Hoops have a game in hand, they are six points behind the current leaders, with Lennon's side under pressure of retaining the title for the tenth time in a row.
Celtic's previous league game ended in a dramatic 3-3 draw against Aberdeen as the Dons scored a penalty in extra time, preventing the Glaswegian side from gaining the full three points.
Lille Europa League form: W
Lille form (all competitions): DWWWWD
Celtic Europa League form: L
Celtic form (all competitions): DLLWWW
Christophe Galtier could field a similar side to the one which beat Sparta Prague last week, with the French manager hoping to rest some key players for their upcoming game against Lyon at the weekend.
Yusuf Yazici will be expecting to make the starting XI on Thursday, following his impressive display in their previous Europa League match, scoring a hat-trick against Sparta Prague.
Burak Yilmaz should also get the nod, with Lille's free transfer in excellent form since joining the French side - netting four times since his arrival.
Meanwhile, Celtic may have some problems as they head into Thursday's clash against Lille, after a set of players tested positive for COVID-19 while on international duty.
The Celtic manager also admitted that it will be a few weeks until we see James Forrest back in the squad, with the winger expected to return in early November.
Lille possible starting lineup:
Maignan; Pied, Fonte, Botman, Bradaric; Yazici, Xeka, Soumare, Bamba; Yilmaz, Ikone
Celtic possible starting lineup:
Barkas; Welsh, Bitton, Ajer; Frimpong, Ntcham, Brown, McGregor, Laxalt; Ajeti, Edouard
We say: Lille 2-1 Celtic
Celtic will be hoping to bounce back from a tough couple of weeks, however it will be difficult against a dominant Lille side, who have excelled at both ends of the pitch. Lille's impressive defensive record, in particular, will prove difficult against the visitors - with the Hoops highly unlikely to get more than one goal past Los Dogues.