Neither second-placed Queens Park Rangers or third-placed Burnley are in Championship action this weekend, meaning that the Foxes could open up a sizable gap with a seventh straight league win.
The hosts boast the joint best home record in the division so far this season, losing just once and picking up 32 points in front of their own fans, as well as scoring a league-high 27 goals.
Only Burnley have managed to take any points off Nigel Pearson's side in their last five home games, and the last two matches at the King Power Stadium have yielded nine goals for the hosts.
Leicester will face a tough test in the shape of playoff-chasing Middlesbrough, however, as the visitors also come into this match in good form.
They are unbeaten in their last six Championship games, picking up 16 points from a possible 18 in that time to lift them to ninth in the table, five points off the playoffs.
Only Derby and Leicester have scored more goals than Middlesbrough in the league this season, and manager Aitor Karanka appears to have sorted out the team's defensive issues as well, with five clean sheets in their last six Championship outings.
Having only won one of their first nine away games this season, Boro have improved on their travels recently, with two wins from their last three and no defeats in four.
Another victory would see them climb at least one place in the table, while they could move as high as seventh depending on the result in Blackburn Rovers' game against Derby County.
Possible starting lineups
Leicester: Schmeichel; De Laet, Moore, Morgan, Konchesky; Knockaert, James, Drinkwater, Dyer; Vardy, Nugent
Middlesbrough: Given; Williams, Gibson, Ayala, Friend; Leadbitter, Whitehead, Carayol, Emnes, Ledesma; Main
Sports Mole says: 2-0