The Foxes could move into the Championship's automatic promotion places with a win, while Barnsley could haul themselves out of the bottom three if they secure victory.
Leicester come into the match off the back of a 2-1 success over East Midlands rivals Derby County in the League Cup on Tuesday evening.
Barnsley have lost their last three matches, including Saturday's heavy defeat at the hands of Watford.
Possible starting lineups
Leicester: Schmeichel; De Laet, Morgan, Moore, Konchesky; Knockaert, Drinkwater, King, Dyer; Nugent, Vardy
Barnsley: Butland; Wiseman, Ramage, Cranie, Kennedy; Mellis, Perkins, Dawson, Etuhu; Scotland, O'Grady
Sports Mole says: 2-1