Lazio vs. Genoa (Sunday, 11.30am)
Meanwhile, the visitors are hoping to avoid a third consecutive away defeat in the top-flight for the first time since October 2019.
We say: Lazio 3-1 Genoa
Goals are to be expected on Sunday, as the net has been found 41 times in the last 10 meetings between Lazio and Genoa in all competitions, with both teams scoring on nine occasions.
The hosts will be the favourites for this clash, and we feel that they have enough quality in the final third to outscore their opponents and secure all three points at the Stadio Olimpico.
Sassuolo vs. Atalanta (Sunday, 2.00pm)
The attack-focused teams convene with Gian Piero Gasperini's men on a run of six wins from seven league games, while the hosts are enjoying a return to the peak of their powers - having posted four straight successes coming into this weekend.
We say: Sassuolo 1-3 Atalanta BC
In a clash that almost cannot fail to entertain, free-scoring Atalanta can surge to victory, thanks to their endless number of attacking options and renewed threat from out wide.
Sassuolo's best-ever winning run in Serie A may come to an end, but a positive climax to the season can still be achieved now the Neroverdi have rediscovered their fluent former selves.
Napoli vs. Cagliari (Sunday, 2.00pm)
Having remained in the hunt for a top-four finish by posting back-to-back wins, the Partenopei will now seek to extend their recent dominance over the Isolani, who have managed to string together three successive wins to keep hopes of a great escape alive.
We say: Napoli 3-1 Cagliari
With much to play for at both ends of the Serie A standings, this fixture promises to be hard fought throughout the 90 minutes.
While Cagliari have shown true grit with backs against the wall - and a talented squad can still prolong their four-year stay in the top flight in the coming weeks - Gennaro Gattuso's free-scoring Napoli side can exploit the Isolani's defensive deficiencies to take all three points.
Bologna vs. Fiorentina (Sunday, 2.00pm)
Meanwhile, La Viola have collected four points from their last two league games but sit just three points above the drop zone heading into the final five fixtures of the campaign.
We say: Bologna 1-2 Fiorentina
There is still work to be done by both Bologna and Fiorentina if they are to avoid relegation this campaign and claiming three points on Sunday would help in their bid to survive.
The two teams have struggled defensively throughout this campaign, but we feel that the form of Vlahovic will give La Viola the edge at the Renato Dall'Ara Stadium.
Udinese vs. Juventus (Sunday, 5.00pm)
While the Bianconeri are bound for a nail-biting climax to the Serie A season - but with only Champions League qualification at stake, rather than their defence of the Scudetto - the hosts are close to confirming their survival in the top flight: sitting eight points above the drop zone.
We say: Udinese 0-2 Juventus
Having lost each of their last three home games by one goal to nil, Udinese appear ill-placed to take advantage of Juve's current inconsistencies, so may find that their barren run on Fruilian soil continues.
A lack of goal threat often undermines the hosts' neat play, so despite the promptings of in-demand skipper Rodrigo De Paul, expect them to come out of this encounter empty-handed - as their more illustrious Bianconeri counterparts take another uncertain step towards a top-four finish.
Sampdoria vs. Roma (Sunday, 7.45pm)
While the Giallorossi's Europa League destruction at the hands of Manchester United was the latest in a string of setbacks for Paulo Fonseca's fast-fading team, Samp have been cruising along just inside the top half of the table and will have a stress-free run-in.
We say: Sampdoria 1-1 Roma
Roma have just a handful of games left to salvage something from the ashes of their season after losing four of their last seven matches, so even a point away to a tricky Sampdoria side would be a welcome tonic at this stage.
Apparently incapable of keeping a clean sheet in recent weeks, the Giallorossi can perhaps take advantage of Samp's possible lack of urgency, given they only have a top-half finish to defend in the final rounds of the season.